Levodopa improves motor deficits but can further disrupt cognition in a macaque Parkinson model.
Identifieur interne : 000938 ( Main/Exploration ); précédent : 000937; suivant : 000939Levodopa improves motor deficits but can further disrupt cognition in a macaque Parkinson model.
Auteurs : Jay S. Schneider [États-Unis] ; Elsa Y. Pioli ; Yang Jianzhong ; Qin Li ; Erwan BezardSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2013.
English descriptors
- KwdEn :
- 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (administration & dosage), Analysis of Variance, Animals, Antiparkinson Agents (therapeutic use), Cognition Disorders (chemically induced), Cognition Disorders (physiopathology), Conditioning, Operant (drug effects), Disease Models, Animal, Levodopa (therapeutic use), MPTP Poisoning (complications), MPTP Poisoning (drug therapy), Macaca fascicularis, Male, Movement (drug effects), Photic Stimulation, Time Factors.
- MESH :
- chemical , administration & dosage : 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
- chemical , therapeutic use : Antiparkinson Agents, Levodopa.
- chemically induced : Cognition Disorders.
- complications : MPTP Poisoning.
- drug effects : Conditioning, Operant, Movement.
- drug therapy : MPTP Poisoning.
- physiopathology : Cognition Disorders.
- Analysis of Variance, Animals, Disease Models, Animal, Macaca fascicularis, Male, Photic Stimulation, Time Factors.
Abstract
Levodopa effectively relieves motor symptoms in Parkinson's disease (PD), but has had inconsistent effects on cognition, even worsening some aspects of cognitive functioning. Therefore, remediation of PD cognitive deficits is a major unmet need. However, drug development efforts have been hampered by lack of an animal model in which motor and cognitive deficits can be examined simultaneously.
DOI: 10.1002/mds.25258
PubMed: 23238827
Affiliations:
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Le document en format XML
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Pioli</name></author><author><name sortKey="Jianzhong, Yang" sort="Jianzhong, Yang" uniqKey="Jianzhong Y" first="Yang" last="Jianzhong">Yang Jianzhong</name></author><author><name sortKey="Li, Qin" sort="Li, Qin" uniqKey="Li Q" first="Qin" last="Li">Qin Li</name></author><author><name sortKey="Bezard, Erwan" sort="Bezard, Erwan" uniqKey="Bezard E" first="Erwan" last="Bezard">Erwan Bezard</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2013">2013</date><idno type="doi">10.1002/mds.25258</idno><idno type="RBID">pubmed:23238827</idno><idno type="pmid">23238827</idno><idno type="wicri:Area/PubMed/Corpus">000B37</idno><idno type="wicri:Area/PubMed/Curation">000B37</idno><idno type="wicri:Area/PubMed/Checkpoint">000952</idno><idno type="wicri:Area/Ncbi/Merge">003926</idno><idno type="wicri:Area/Ncbi/Curation">003926</idno><idno type="wicri:Area/Ncbi/Checkpoint">003926</idno><idno type="wicri:Area/Main/Merge">000938</idno><idno type="wicri:Area/Main/Curation">000938</idno><idno type="wicri:Area/Main/Exploration">000938</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Levodopa improves motor deficits but can further disrupt cognition in a macaque Parkinson model.</title><author><name sortKey="Schneider, Jay S" sort="Schneider, Jay S" uniqKey="Schneider J" first="Jay S" last="Schneider">Jay S. Schneider</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA. jay.schneider@jefferson.edu</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Pioli, Elsa Y" sort="Pioli, Elsa Y" uniqKey="Pioli E" first="Elsa Y" last="Pioli">Elsa Y. Pioli</name></author><author><name sortKey="Jianzhong, Yang" sort="Jianzhong, Yang" uniqKey="Jianzhong Y" first="Yang" last="Jianzhong">Yang Jianzhong</name></author><author><name sortKey="Li, Qin" sort="Li, Qin" uniqKey="Li Q" first="Qin" last="Li">Qin Li</name></author><author><name sortKey="Bezard, Erwan" sort="Bezard, Erwan" uniqKey="Bezard E" first="Erwan" last="Bezard">Erwan Bezard</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (administration & dosage)</term><term>Analysis of Variance</term><term>Animals</term><term>Antiparkinson Agents (therapeutic use)</term><term>Cognition Disorders (chemically induced)</term><term>Cognition Disorders (physiopathology)</term><term>Conditioning, Operant (drug effects)</term><term>Disease Models, Animal</term><term>Levodopa (therapeutic use)</term><term>MPTP Poisoning (complications)</term><term>MPTP Poisoning (drug therapy)</term><term>Macaca fascicularis</term><term>Male</term><term>Movement (drug effects)</term><term>Photic Stimulation</term><term>Time Factors</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiparkinson Agents</term><term>Levodopa</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Cognition Disorders</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>MPTP Poisoning</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Conditioning, Operant</term><term>Movement</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>MPTP Poisoning</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Cognition Disorders</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Analysis of Variance</term><term>Animals</term><term>Disease Models, Animal</term><term>Macaca fascicularis</term><term>Male</term><term>Photic Stimulation</term><term>Time Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Levodopa effectively relieves motor symptoms in Parkinson's disease (PD), but has had inconsistent effects on cognition, even worsening some aspects of cognitive functioning. Therefore, remediation of PD cognitive deficits is a major unmet need. However, drug development efforts have been hampered by lack of an animal model in which motor and cognitive deficits can be examined simultaneously.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Pennsylvanie</li></region></list><tree><noCountry><name sortKey="Bezard, Erwan" sort="Bezard, Erwan" uniqKey="Bezard E" first="Erwan" last="Bezard">Erwan Bezard</name><name sortKey="Jianzhong, Yang" sort="Jianzhong, Yang" uniqKey="Jianzhong Y" first="Yang" last="Jianzhong">Yang Jianzhong</name><name sortKey="Li, Qin" sort="Li, Qin" uniqKey="Li Q" first="Qin" last="Li">Qin Li</name><name sortKey="Pioli, Elsa Y" sort="Pioli, Elsa Y" uniqKey="Pioli E" first="Elsa Y" last="Pioli">Elsa Y. Pioli</name></noCountry><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Schneider, Jay S" sort="Schneider, Jay S" uniqKey="Schneider J" first="Jay S" last="Schneider">Jay S. 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